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医学部
学科及导师简介(生物学)Program and Supervisor Profiles(Biology)
作者:        发布时间:2022-01-11 11:16        点击数:


生物学Biology  (医学部)

NAME OF MAJOR

Biology

PROGRAM OVERVIEW

This PhD program in Biology is led by Professor Wei-Guo Zhu, Dean of the Shenzhen University School of Medicine. This cross-disciplinary program will ensure that students are familiar with scientific frontiers in the life sciences, and gain theoretical knowledge, professional experience in biological techniques used in the research laboratory setting and science-based critical thinking. Graduates of this program will have the ability to undertake independent research and work creatively in the field of biomedical science.

Main research fields:

1. Biochemistry and Molecular Biology

Students will study the structure and function of biological macromolecules such as nucleic acids and proteins; explore the biochemical basis and regulatory mechanisms of cell metabolism and homeostasis; and make scientific breakthroughs in the fields of genomic homeostasis, the molecular mechanisms of autophagy, and the pathogenic mechanisms and early diagnosis of major diseases. The mentors in this subprogram have made many breakthroughs in above-mentioned areas and thus are internationally competitive and renowned.

2. Cancer Biology

Students will focus on the biological basis of DNA replication, DNA damage repair, cancer chemoradiotherapy and immunotherapy, and the molecular mechanisms underlying the tumor microenvironment regulating pancreatic cancer metastasis; interpret the molecular mechanisms of maintaining genomic stability; explore new carcinogenic mechanisms and cancer therapeutic targets; and develop new anticancer lead compounds. The mentors in this subprogram are world renowned experts who have  published numerous original research papers in high-profile international journals such as Molecular Cell, Cell Research, and PNAS. In addition, they continuously host an international conference series on DNA repair.

CORE COURSES

Frontiers in Life Science, Academic and Professional English, Biochemistry and Molecular Biology, Advanced Cell Biology and Disease, Cancer Biology

CAREER PROSPECTS

Graduates will be able to follow careers in the biomedical sciences for both academic and industry.

Consultation

Email: molmed.hsc@szu.edu.cn                  





中文姓名

武田俊一

 

英文名

SHUNICHI TAKEDA

联系邮箱

stakeda@szu.edu.cn

中文简介

武田教授的实验室主要研究抗癌药物的分子机制。我们的研究目标是提供一种可预测不同抗癌疗法对不同癌症患者治疗疗效的情况,并为每个患者提供最佳的治疗。每个患者的癌症特征都有很大的不同,例如,每个癌基因的活性和抗癌治疗的疗效在每个乳腺癌患者之间都有很大的不同。在不久的将来,有可能可以确定每个恶性肿瘤病人中许多基因的活性状态。抗癌药物会杀死循环中的正常细胞,产生非常严重的副作用。因此,在实际治疗前预测抗癌药物的疗效和副作用的发生是非常重要的。武田教授的实验室一直致力于干扰人类癌细胞中的基因研究,并检测每个基因的活性对抗癌药物疗效的影响。本研究将有助于通过分析恶性肿瘤中基因的活性状态来预测不同疗法的疗效。这项研究也让学生系统地学习基因研究的方法,包括基因破坏和基因破坏细胞的许多表型分析,与大家分享更多基因的突变细胞进行科学研究。

英文简介

Prof. Takeda’s laboratory has investigated molecular mechanisms underlying anti-cancer drugs. The goal of our study is to develop the method of predicting the efficacy of various anti-cancer therapies on individual cancer patients and to offer the best therapy to each patient. The character of cancers arising in each patient significantly vary, for example, each oncogene’s activity and the efficacy of anti-cancer therapies are very different from one breast cancer patient to another. It is possible in the near future to determine the activity status of many genes in each patient’s malignant tumor. Anti-cancer drugs kill actively cycling normal cells causing very severe side effects. Thus, it is very important to anticipate the efficacy of anti-cancer drugs and the occurrence of side effects before actual treatments. Prof. Takeda’s laboratory has been disrupting genes in human cancer cells and examining the effect of each gene’s activity on the efficacy of anti-cancer drugs. This study will contribute to the prediction of different therapies’ efficacy by analyzing the activity status of genes in malignant tumors. This study also allows students to systematically learn methods of the genetic study, including gene disruption and many phenotypic analyses of gene-disrupted cells, sharing mutant cells of many genes with colleagues.


 


中文姓名

许兴智

英文名

XU, Xingzhi

联系邮箱

Xingzhi.Xu@szu.edu.cn

中文简介

深圳大学特聘教授、医学部副主任,国际先进材料协会(IAAM)会士,《Genome Instability & Disease》常务主编、中国细胞生物学学会细胞信号转导分会副会长(2015-2023)。长期致力于DNA损伤应答、DNA复制及复制应激、基因组稳定性维持的研究,并开发靶向基因组稳定性的抗癌先导化合物。在国际主流杂志发表SCI论文100余篇;主编《肿瘤生物学导论》(科学出版社,2014)。2011年创建DNA损伤应答北京市重点实验室并任主任(2011-2017);2010年创办并连续主办DNA损伤应答与人类疾病国际研讨会(isDDRHD)年会系列并成为有国际影响力的品牌会议,是中国DNA修复领域的核心召集人。

英文简介

Distinguished Professor of Shenzhen University, Vice Dean of School of Medicine, Fellow of the International Association for Advanced Materials (IAAM), Deputy Editor-in-chief of Genome Instability & Disease, Vice President of Chinese Society for Cell Signal Transduction, CSCB (2015-2023). He has long been devoted to the research of DNA damage response, DNA replication and replication stress response, and maintenance of genome stability, and has developed anticancer lead compounds targeting genome homeostasis. He has published more than 100 SCI papers in international mainstream journals; edited "Principles of Cancer Biology" (Science Press, 2014). In 2011, he founded the Beijing Key Laboratory of DNA Damage Response and served as the director (2011-2017); in 2010, he founded and successively hosted the annual conference series of the international symposium on DNA Damage Response and Human Diseases (isDDRHD), which has become an internationally influential brand conference. Therefore, he becomes the core convener in the field of DNA repair in China.



中文姓名

朱卫国

            

英文名

Wei-Guo Zhu

联系邮箱

zhuweiguo@szu.edu.cn

中文简介

朱教授是深圳大学医学部特聘教授,博士生导师,医学部主任,多项科技部“973”及“863”计划负责人; 国家基金委创新团队负责人;国家基金委重大及重点项目负责人; 国家杰出青年基金获得者。

朱教授聚焦探讨组蛋白修饰酶和相关的组蛋白修饰在DNA损伤应答、细胞自噬及基因调控等过程中的功能及其在肿瘤发生发展中的作用,发现了一系列重要的肿瘤治疗新靶点和新方法,为肿瘤的精准治疗提供了重要的理论基础和实验支撑。他在国际主流期刊发表160余篇研究论文,包括Nature, Nature Cell Biology, Molecular Cell, PNAS等,被引用15000余次。学术研究主要包括以下三个方面:

1.识别一系列参与肿瘤细胞DNA损伤反应的组蛋白修饰位点/组蛋白修饰酶,为肿瘤放疗和化疗提供理论依据;

2. 揭示组蛋白修饰酶在自噬多层次调控中的生物学功能;

3.巩固了蛋白质乙酰化修饰参与肿瘤表观遗传治疗的理论基础。



英文简介

Prof. Zhu is a distinguished Professor of Shenzhen University,  and Dean of the School of Medicine, Shenzhen University, Ph.D Supervisor. He is the head of a number of "973" and "863" programs of the Ministry of Science and Technology of China,  head of the National Funding Commission’s innovation team of NSFC, head of the National Funding Commission’s key R&D program, Recipient of the National Outstanding Distinguished Youth Scientist,as well as the head of major and key projects of the National Foundation Commission of China.

Prof. Zhu focuses on the function of the histone modification enzymes and histone modification in the DNA damage response, autophagy and gene regulation, and its role in cancer development. He found a series of important new targets and methods for cancer treatment, which provides an important theoretical basis and experimental support for the accuracy of tumor therapy. He has published more than 160 research papers in leading international journals including Nature, Nature Cell Biology, Molecular Cell, and PNAS which earned more than 15,000 citations. His academic research mainly includes the following three aspects:

1. Identifying a series of histone modifications sites / histone modifying enzymes that participate in the DNA damage response of tumor cells, providing a theoretical basis for tumor radiotherapy and chemotherapy.

2. Revealing the biological functions of histone-modifying enzymes in the multi-level regulation of autophagy.

Consolidating the theoretical basis for the involvement of protein acetylation modification in tumor epigenetic therapy.





中文姓名

楼慧强

(照片)

英文名

Huiqiang Lou

联系邮箱

lou@szu.edu.cn

中文简介

楼慧强实验室致力于探讨肿瘤发生的两种假说:基因组不稳定性和代谢紊乱,尤其是两个假说之间的关联。我们综合运用遗传学、生物化学、细胞生物学及系统生物学等手段,一方面研究DNA复制及其关联事件出错的原因;另一方面研究营养(糖)代谢如何影响DNA复制与基因组稳定性。近五年代表作发表在Genes & Dev, EMBOJ, Cell Rep, EMBO Rep, CMLS, PLoS Genet 等高水平杂志。

英文简介

The Lou Group is devoted to uncover the potential crosstalk between metabolic dysregulation and genome instability, the two major resources which are considered to underlie cancer initiation. We apply multidisciplinary approaches such as genetics, biochemistry, cell biology, quantitative biology and synthetic biology to investigate DNA replication, co-replication events and whether/how sugar metabolism affects DNA replication/genome integrity. Our recent high-impact publications include Genes & Dev, EMBOJ, Cell Rep, EMBO Rep, CMLS, PLoS Genet.  






 



中文姓名

程永现

英文名

Cheng Yong-Xian

联系邮箱

yxcheng@szu.edu.cn

中文简介

程永现教授长期从事中药药效物质研究,创建了中医治则治法指导下阐明中药药效物质的新模式,形成了围绕慢性疾病运用“衷中参西”方法揭示中药药效物质的新体系,并在树脂、灵芝、昆虫三大特色中药研究方面取得突破性进展。其研究工作涉及中药化学成分分离、鉴定、活性发现及采用化学生物学方法鉴定靶标。主持(过)NSFC-云南联合基金重点项目、国家自然科学基金重点项目、十二五国家重大新药创制专项课题、十三五国家重点研发计划课题等。曾先后获云南省自然科学一等奖、广东省科技进步一等奖、中华医学科技一等奖、国家科技进步二等奖等。已发表论文300余篇、获授权专利50余件,培养硕士和博士研究生100余名。

英文简介

My research interests are on the isolation, structural characterization, biological evaluation, structural optimization, and mechanistic exploration of natural products produced by insects, Ganoderma fungi, and plant resins. Moreover, our research deals with target identification of bioactive small molecules using chemical biology approaches. I have focused on compounds with potential reno-protective and neuro-protective effects inspired by traditional Chinese medicine philosophy or bionic concepts. In particular, I made great progress on nonpeptide small molecules from the insects and aromatic meroterpenoids from Ganoderma fungi, which represents pioneering work in this field. Given these achievements, I was supported by the National Science Fund for Distinguished Young Scholars in China. My future research will utilize biotic and abiotic stressors, such as light induction, to create chemical and biological diversities of metabolites from the above materials. Under the support of projects such as National Major Scientific and Technological Special Project for “Significant New Drugs Development” during the Eleventh and Twelfth Five-year Plan Periods, NSFC-Joint Foundation of Yunnan Province, National Natural Science Foundation of China, Knowledge Innovation Project of the Chinese Academy of Sciences, and West Light Foundation of the Chinese Academy of Sciences, I have published 300 papers (e.g. JASN, Org Lett, J Nat Prod) and applied for 50 patents. I am currently mentoring two PhD candidates and 20 MSc candidates.


 



中文姓名

吕德生

英文名

Desheng Lu

联系邮箱

delu@szu.edu.cn

中文简介

吕德生教授是深圳大学医学部特聘教授,深圳大学医学部药理学系主任,深圳市孔雀计划B类人才。他的主要研究方向为肿瘤干细胞相关信号通路(包括Wnt信号通路)、肿瘤干细胞和抗肿瘤新药的研发。1998年,获得加拿大多伦多大学博士学位,迄今已发表60多篇科学论文,论文已被引用超过3400次,H-指数为27目前担任PNAS、 Blood、 Cancer Research、Clinical Cancer Research等国际著名杂志特约审稿专家,现任深圳市分析测试协会医学测试专委会副主任委员。

英文简介

Prof. Lu is a distinguish professor and Chairman of Department of Pharmacology in Shenzhen University Health Science Center. He won the Shenzhen Peacock Talent Award (Class B). His main research interests are cancer stem cells-associated signaling transduction (especially Wnt signaling pathway), cancer stem cells and anti-cancer drug discovery. He received his doctorate in medical genetics from University of Toronto in 1998. So far, he has published more than 60 scientific papers, including many high-level articles published in some prestigious international journals. These papers have been cited more than 3400 times with an H-index of 27. He has served as a reviewer of internationally renowned journal such as PNAS, Blood, Cancer Research, and Clinical Cancer Research. He is currently the deputy chairman of the Medical Testing Committee of Shenzhen Analytical Testing Association.


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